Novel redox-responsive nanogels based on poly(ionic liquid)s for the triggered loading and release of cargos

doi:10.1039/c5ra21820a

	Novel redox-responsive nanogels based on poly(ionic liquid)s for the triggered loading and release of cargos
	Miao, Congcong 1; Li, Feng1 ; Zuo, Yong 1; Wang, Rongmin1 ; Xiong, Yubing1,2
	2016
发表期刊	RSC Advances
ISSN	2046-2069
卷号	6 期号:4 页码:3013-3019
摘要	The unique disulfide chemistry has been widely explored for novel and versatile delivery systems addressing both intracellular and extracellular barriers. In this study, novel redox-responsive nanogels were fabricated by radical copolymerization of ionic liquid (IL)-based monomers, 1,n-butanediyl-3,3′-bis-1-vinylimidazolium dibromide ([CnVIm]Br, n = 4, 6), and disulphide dimethacrylate (DSDMA) in selective solvents. The as-synthesized nanogels were characterized using scanning electron microscopy (SEM), Fourier transform infrared (FTIR) spectroscopy, thermogravimetric analyses (TG), dynamic laser scattering (DLS) and zeta (ζ)-potential measurements. The results demonstrated that the sizes of poly(ionic liquid) (PIL)-based nanogels can be tuned by the feed ratio of the monomers and DSDMA. Moreover, the redox-response performances of these nanogels were evaluated through the size variation in the presence of dithiothreitol (DTT) and benzoyl peroxide (BPO). The capability of PIL-based nanogels for controlled release was also investigated by using rhodamine B (RhB) as prototype model drug. It was found that DTT-triggered release of RhB could be achieved. Therefore, a redox-triggered loading and release matrix can be conveniently fabricated via PIL-based nanogels. And it can also be potentially used as a controlled carrier in biological medicine. © The Royal Society of Chemistry 2016.
关键词	Benzoyl peroxide Fourier transform infrared spectroscopy Ionic liquids Monomers Nanostructured materials Rhodium compounds Scanning electron microscopy Sulfur compounds Targeted drug delivery Thermogravimetric analysis Controlled release Delivery systems Dynamic laser scattering Poly(ionic liquid)s Potential measurements Radical copolymerization Selective solvents Triggered release
DOI	10.1039/c5ra21820a
收录类别	EI ; SCIE
语种	英语
WOS研究方向	Chemistry
WOS类目	Chemistry, Multidisciplinary
WOS记录号	WOS:000368193500057
出版者	Royal Society of Chemistry
EI入藏号	20160201802500
EI主题词	Controlled drug delivery
EI分类号	761 Nanotechnology ; 801 Chemistry ; 804 Chemical Products Generally
原始文献类型	Journal article (JA)
引用统计	被引频次：25[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://ir.nwnu.edu.cn/handle/39RV6HYL/31185
专题	实体学院_化学化工学院_化工系实体学院_化学化工学院机关部门（群众团体）_实验室与设备管理处
通讯作者	Xiong, Yubing
作者单位	1.Northwest Normal Univ, Coll Chem & Chem Engn, Key Lab Ecoenvironm Related Polymer Mat, Minist Educ, Lanzhou 730070, Peoples R China; 2.Max Planck Inst Polymer Res, D-55128 Mainz, Germany
第一作者单位	化工系
通讯作者单位	化工系
第一作者的第一单位	化工系
推荐引用方式 GB/T 7714	Miao, Congcong,Li, Feng,Zuo, Yong,et al. Novel redox-responsive nanogels based on poly(ionic liquid)s for the triggered loading and release of cargos[J]. RSC Advances,2016,6(4):3013-3019.
APA	Miao, Congcong,Li, Feng,Zuo, Yong,Wang, Rongmin,&Xiong, Yubing.(2016).Novel redox-responsive nanogels based on poly(ionic liquid)s for the triggered loading and release of cargos.RSC Advances,6(4),3013-3019.
MLA	Miao, Congcong,et al."Novel redox-responsive nanogels based on poly(ionic liquid)s for the triggered loading and release of cargos".RSC Advances 6.4(2016):3013-3019.