A novel electrochemical sensor based on microporous polymeric nanospheres for measuring peroxynitrite anion released by living cells and studying the synergistic effect of antioxidants (vol 144, pg 6905, 2019)

doi:10.1039/d2an90039d

	A novel electrochemical sensor based on microporous polymeric nanospheres for measuring peroxynitrite anion released by living cells and studying the synergistic effect of antioxidants (vol 144, pg 6905, 2019)
	Liu, Fuxin; Li, Lin; Zhang, Binyan; Fan, Weizhou; Zhang, Rongjin; Liu, Guoan; Liu, Xiuhui
	2022-06-13
发表期刊	ANALYST
ISSN	0003-2654
卷号	147 期号:12 页码:2870-2870
摘要	Peroxynitrite anion (ONOO-) is a crucial reactive nitrogen species (RNS), which has aroused immense research interest in the biological and biomedical fields because aberrant expression levels of ONOO- are related to many diseases. In this work, a novel electrochemical sensor is described for the detection of peroxynitrite anion (ONOO-) released from living cells. It is constructed with a glassy carbon electrode (GCE) decorated with a nanocomposite (CTS-MPNS) synthesized from chitosan (CTS) functionalized microporous polymeric nanospheres (MPNS). The prepared CTS-MPNS/GCE sensor shows a supernormal manifestation in measuring ONOO- in a wide range of concentrations from 3.83 nM to 0.104 mM, and the detection limit is as low as 1.28 nM (S/N = 3), which makes it possible to detect trace amounts of ONOO- released from U87 cells. Significantly, the synergistic effect of different antioxidants on scavenging ONOO- in biological systems is further studied by an electrochemical method for the first time, which provides an efficient strategy for protecting cells against oxidative stress. The developed platform and the efficient strategy may pave the way for their future applications in the field of biomedicine and the treatment of cancer diseases.
DOI	10.1039/d2an90039d
收录类别	SCIE
语种	英语
WOS研究方向	Chemistry
WOS类目	Chemistry, Analytical
WOS记录号	WOS:000800113300001
出版者	ROYAL SOC CHEMISTRY
原始文献类型	Correction
引用统计	被引频次[WOS]：0 [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://ir.nwnu.edu.cn/handle/39RV6HYL/79200
专题	实体学院_化学化工学院_化工系实体学院_生命科学学院实体学院_化学化工学院实体学院_传媒学院（新闻学院）
通讯作者	Liu, Xiuhui
作者单位	Northwest Normal Univ, Coll Chem & Chem Engn, Key Lab Bioelectrochem Environm Anal Gansu Prov, Lanzhou 730070, Peoples R China
第一作者单位	化工系
通讯作者单位	化工系
第一作者的第一单位	化工系
推荐引用方式 GB/T 7714	Liu, Fuxin,Li, Lin,Zhang, Binyan,et al. A novel electrochemical sensor based on microporous polymeric nanospheres for measuring peroxynitrite anion released by living cells and studying the synergistic effect of antioxidants (vol 144, pg 6905, 2019)[J]. ANALYST,2022,147(12):2870-2870.
APA	Liu, Fuxin.,Li, Lin.,Zhang, Binyan.,Fan, Weizhou.,Zhang, Rongjin.,...&Liu, Xiuhui.(2022).A novel electrochemical sensor based on microporous polymeric nanospheres for measuring peroxynitrite anion released by living cells and studying the synergistic effect of antioxidants (vol 144, pg 6905, 2019).ANALYST,147(12),2870-2870.
MLA	Liu, Fuxin,et al."A novel electrochemical sensor based on microporous polymeric nanospheres for measuring peroxynitrite anion released by living cells and studying the synergistic effect of antioxidants (vol 144, pg 6905, 2019)".ANALYST 147.12(2022):2870-2870.